赵款，男，博士，副教授，硕士/博士生导师，预防兽医系系主任，主要研究方向为动物病毒的分子流行病学、反向遗传学、免疫与致病机制、新型生物制品的研发。
电子信箱：zhaokuan519@126.com
通讯地址：河北省保定市莲池区乐凯南大街2596号河北农大西校区
教育/工作经历：
2009.9-2013.6 河北农业大学动物科技学院，动物医学专业，农学学士；
2013.9-2016.6 中国农科院哈尔滨兽医研究所，兽医专业，兽医硕士；
2016.9-2019.6 中国农科院上海兽医研究所，预防兽医学专业，农学博士；
2019.8至今，河北农业大学动物医学院，副教授。
科研项目
1. 猪繁殖与呼吸综合征病毒拮抗cGAS-STING抗病毒作用的分子机制研究，32102644，国自然青年基金/国家自然基金委，30万，主持。
2. 负载牛扰素α/γ的聚合物纳米颗粒抑制牛病毒性腹泻病毒复制的分子机制研究，C2022204249, 河北省生物农业联合基金重点项目，55万，主持。
3.河北省重点研发计划项目，猪A型塞内卡病毒表位缺失标记灭活疫苗的研制，30万，在研，主持。
4.河北农业大学人才专项，猪A型塞内卡病毒反向遗传的构建及应用，20万，在研，主持。
代表性论文：
(1) Kuan Zhao#, Jia-Cong Gao#, Jun-Yao Xiong#, Jin-Chao Guo, Yong-Bo Yang, Cheng-Gang Jiang, Yan-Dong Tang, Zhi-Jun Tian, Xue-Hui Cai, Guang-Zhi Tong, Tong-Qing An*, Two residues in NSP9 contribute to the enhanced replication and pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus, Journal of Virology, 2018, 92(7):e02209-17（中科院二区TOP）
(2) Kuan Zhao, Chao Ye, Xiao-Bo Chang, Cheng-Gang Jiang, Shu-Jie Wang, Xue-Hui Cai, Guang-Zhi Tong, Zhi-Jun Tian, Mang Shi, Tong-Qing An*, Importation and recombination are responsible for the latest emergence of highly pathogenic porcine reproductive and respiratory syndrome virus in China, Journal of Virology, 2015, 89(20): 10712-10716（中科院二区TOP）
(3) Kuan Zhao#, Xiao-Ran Guo#, Shuai-Feng Liu, Xiao-Na Liu,Ying Han, Lu-Lu Wang, Bai-Shi Lei, Wu-Chao-Zhang, Li-Min Li, Wan-Zhe Yuan*, 2B and 3C proteins of Senecavirus A antagonize the antiviral activity of DDX21 via the caspase-dependent degradation of DDX21. Frontiers in Immunology, 2022, 3711（中科院二区TOP）
(4) Xiao-Na Liu#, Li-Wei Li#, Fei Gao, Yi-Feng Jiang, Wan-Zhe Yuan, Guo-Xin Li, Ling-Xue Yu, Yan-Jun Zhou, Guang-Zhi Tong, Kuan Zhao*, cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity. Frontiers in Immunology, 2022, 13（中科院二区TOP）
(5) Kuan Zhao#, Li-Wei Li#, Yi-Feng Jiang, Fei Gao, Yu-Jiao Zhang, Wen-Ying Zhao, Guo-Xin Li, Ling-Xue Yu, Yan-Jun Zhou, Guang-Zhi Tong*, Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination. Veterinary Microbiology, 2019, 233, 140-146（中科院二区TOP）
(6) Xiao-Na Liu, Xiao-Ran Guo, Ying Han, Tian Tian, Jian Sun, Bai-Shi Lei, Wu-Chao-Zhang, Wan-Zhe Yuan*, Kuan Zhao*, The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection, Frontiers in microbiology, 2022, 13（中科院二区TOP）
(7) Kuan Zhao#, Xue-Piao Hao#, Bai-Shi Lei, Shi-Shan Dong, Jin-Fei Wang, Wu-Chao Zhang, Jian-Chang Wang, Wan-Zhe Yuan, Emergence and genomic analysis of a novel ostrich-origin GPV-related parvovirus in China, Poultry Science, 2022, 101929（中科院二区TOP）
(8) Xiao-Ran Guo#, Kuan Zhao#, Xiao-Na Liu, Bai-Shi Lei, Wu-Chao Zhang, Xiu-Li Li, Wan-Zhe Yuan*, Construction and Generation of a Recombinant Senecavirus a Stably Expressing the NanoLuc Luciferase for Quantitative Antiviral Assay, Frontiers in microbiology, 2021, 2838（中科院二区TOP）
(9) Li-Wei Li#, Kuan Zhao#, Fei Gao, Yi-Feng Jiang, Tong-Ling Shan, Wu Tong, Hao Zheng, Ling-Xue Yu, Guo-Xin Li, Zhi-Yong Ma, Guang-Zhi Tong*, Restriction of porcine reproductive and respiratory syndrome virus replication by galectin-1, Veterinary Microbiology, 2019, 235, 310-318（中科院二区TOP）
(10) Jun-Yao Xiong#, Xing-Yang Cui#, Kuan Zhao#, Qian Wang, Xin-Yi Huang, Dong-Yan Li, Fang Yu, Yong-Bo Yang, Di Liu, Zhi-Jun Tian, Xue-Hui Cai, Tong-Qing An*, A Novel Motif in the 3′-UTR of PRRSV-2 Is Critical for Viral Multiplication and Contributes to Enhanced Replication Ability of Highly Pathogenic or L1 PRRSV, Viruses, 2022, 14-2, 166（中科院三区）
(11) Kuan Zhao, Shixia Zhang, Xiaona Liu, Xiaoran Guo, Zhaomeng Guo, Xiaozhan Zhang*, Wanzhe Yuan*. The game between host antiviral innate immunity and immune evasion strategies of Senecavirus A-A cell biological perspective[J]. Frontiers in Immunology, 2022, 13: 7866. （中科院二区TOP）
(12) Kuan Zhao#, Xiuli Li#, Baishi Lei, Ying Han, Tongqing An, Wuchao Zhang, Huiwen Zhang, Bosen Li, Wanzhe Yuan, Recombinant porcine Interferon-α and Interleukin-2 fusion protein (rPoIFNα+ IL-2) shows potent anti-pseudorabies virus activity in vitro and in vivo[J]. Veterinary Microbiology, 2023: 109678. （中科院二区TOP）
